{"id":402,"date":"2024-10-31T13:12:02","date_gmt":"2024-10-31T12:12:02","guid":{"rendered":"https:\/\/staging-scf.agence-nsw.xyz\/champagne-ardenne\/actualites\/conference-21-novembre-2024\/"},"modified":"2024-10-31T13:12:02","modified_gmt":"2024-10-31T12:12:02","slug":"conference-21-novembre-2024","status":"publish","type":"post","link":"https:\/\/staging-scf.agence-nsw.xyz\/champagne-ardenne\/fr\/actualites\/conference-21-novembre-2024\/","title":{"rendered":"Conf\u00e9rence 21 novembre 2024"},"content":{"rendered":"\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>Pr Denis Gigu\u00e8re (Universit\u00e9 Laval, Qu\u00e9bec, Canada)<\/strong><\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\"><strong>Carbohydrate Approach to Multivicinal Fluorinated and Inter-Halide Stereocenters<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In recent years the synthesis of multivicinal organofluorines has gained attention and their properties have been widely studied. Recently our group reported the synthesis of several polyfluorinated analogues of carbohydrates using a\u00a0<em>Chiron<\/em>\u00a0approach and investigated the effect of this element on physicochemical properties such as solution- and solid-state conformation and lipophilicity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To our surprise, multivicinal inter-halides have been ignored from the chemical landscape and efficient synthetic routes leading to these compounds as well as their properties remain unknown.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The synthesis of multivicinal inter-halides stereotriads and -tetrads started from levoglucosan and allowed us to obtain novel compounds with an excellent stereocontrol and good yields.\u00a0The solution-state were established using a\u00a0<em>J<\/em>-based configurational analysis and the lipophilicity was assessed with a log\u00a0<em>P<\/em>determination method based on\u00a0<sup>19<\/sup>F NMR spectroscopy.\u00a0Synthetic application of these compounds in drug discovery was explored with the synthesis of halogenated pitolisant analogues and other medically relevant molecules.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pr Denis Gigu\u00e8re (Universit\u00e9 Laval, Qu\u00e9bec, Canada) Carbohydrate Approach to Multivicinal Fluorinated and Inter-Halide Stereocenters In recent years the synthesis of multivicinal organofluorines has gained attention and their properties have been widely studied. Recently our group reported the synthesis of several polyfluorinated analogues of carbohydrates using a\u00a0Chiron\u00a0approach and investigated the effect of this element on [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-402","post","type-post","status-publish","format-standard","hentry","category-actualites"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Conf\u00e9rence 21 novembre 2024 - SCF R\u00e9gion Champagne-Ardenne<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Conf\u00e9rence 21 novembre 2024 - SCF R\u00e9gion Champagne-Ardenne\" \/>\n<meta property=\"og:description\" content=\"Pr Denis Gigu\u00e8re (Universit\u00e9 Laval, Qu\u00e9bec, Canada) Carbohydrate Approach to Multivicinal Fluorinated and Inter-Halide Stereocenters In recent years the synthesis of multivicinal organofluorines has gained attention and their properties have been widely studied. 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